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Targeting Dihydroceramide Desaturase 1 (Des1): Syntheses of Ceramide Analogues with a Rigid Scaffold, Inhibitory Assays, and AlphaFold2-Assisted Structural Insights Reveal Cyclopropenone PR280 as a Potent Inhibitor

Pablo Rivero, Varbina Ivanova, Xavier Barril, Mireia Casampere, Josefina Casas, Gemma Fabriàs, Yolanda Díaz*, M. Isabel Matheu.*

Biorg. Chem. 2024, 145, 107233-107249

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